WASHINGTON (TNND) — As the Israel conflict with Iran escalates, Iran's supreme leader issued a warning on Wednesday that U.S. intervention would cause "irreparable damage."

Ayatollah Ali Khamenei's warning came after President Donald Trump demanded "UNCONDITIONAL SURRENDER" on Truth Social and alerted the leader that the U.S. knows where he is but has no plans to kill him, "at least not for now."

"The US entering in this matter [war] is 100% to its own detriment. The damage it will suffer will be far greater than any harm that Iran may encounter," the supreme leader posted on X.

In recent days, Trump has hinted at greater American involvement, telling reporters aboard Air Force One after abruptly leaving the G7 summit that he wants "a real end, not a ceasefire," indicating a preference for a decisive resolution over temporary peace.

He met with his team on Tuesday in the Situation Room at the White House to discuss the next steps.

So far, the U.S. has provided defensive support to Israel and additional resources, including aircraft carriers and fighter jets.

Foreign Ministry spokesman Esmail Baghaei also warned on Wednesday that U.S. intervention would risk "all-out war."

Israel launched a "preemptive strike" against Iran last week to head off what they described as an imminent threat that Iran would build nuclear bombs.

Earlier this week, the United States elevated its travel advisory for Israel to "do not travel."

"The security situation in Israel, including Tel Aviv and Jerusalem is unpredictable, and U.S. citizens are reminded to remain vigilant and take appropriate steps to increase their security awareness as security incidents, including mortar and rocket fire and armed UAV intrusions and missiles, can take place without warning," the State Department said in its advisory.

Americans were also warned against traveling "for any reason" to the West Bank due to "terrorism and civil unrest" and to Gaza because of "terrorism and armed conflict."

The latest Israeli strikes hit a facility used to make uranium centrifuges and another that made missile components, the Israeli military said. It said it had intercepted 10 missiles overnight as Iran’s retaliatory barrages diminish. The U.N. nuclear watchdog said Israel had struck two centrifuge production facilities in and near Tehran.

The Israeli military said it also carried out strikes in western Iran, hitting missile storage sites and a loaded missile launcher.

Israeli strikes have hit several nuclear and military sites, killing top generals and nuclear scientists. A Washington-based Iranian human rights group said at least 585 people, including 239 civilians, have been killed and more than 1,300 wounded.

Iran has fired some 400 missiles and hundreds of drones in retaliatory strikes that have killed at least 24 people in Israel and wounded hundreds. Some have hit apartment buildings in central Israel, causing heavy damage, and air raid sirens have repeatedly forced Israelis to run for shelter.

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Editor's note: The Associated Press contributed to this article.